Regulation of Protein Synthesis in Plant Embryo by Protein Phosphorylation

Physicochemical mechanisms of protein regulation by phosphorylation

Phosphorylation offers a dynamic way to regulate protein activity and subcellular localization, which is achieved through its reversibility and fast kinetics. Adding or removing a dianionic phosphate group somewhere on a protein often changes the protein's structural properties, its stability and dynamics. Moreover, the majority of signaling pathways involve an extensive set of protein-protein ...

Regulation of gap junctions by protein phosphorylation.

Gap junctions are constituted by intercellular channels and provide a pathway for transfer of ions and small molecules between adjacent cells of most tissues. The degree of intercellular coupling mediated by gap junctions depends on the number of gap junction channels and their activity may be a function of the state of phosphorylation of connexins, the structural subunit of gap junction channe...

Regulation of Autophagy by Protein Phosphorylation

Regulation of SNARE assembly by protein phosphorylation

Protein phosphorylation is emerging as an important regulatory mechanism that controls the secretory pathway. It enables coupling between the vesicular transport machinery and signaling cascades that are activated by both internal and external stimuli. Proteins that mediate the last steps of membrane fusion such as SNAREs, Sec1/Munc18, Rab proteins, and others undergo post-translational modific...

Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation.

Two genes on chromosome 21, namely dual specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) and regulator of calcineurin 1 (RCAN1), have been implicated in some of the phenotypic characteristics of Down syndrome, including the early onset of Alzheimer disease. Although a link between Dyrk1A and RCAN1 and the nuclear factor of activated T cells (NFAT) pathway has been reported, it ...